Beth Israel Deaconess Medical Center · Harvard Medical School

Vutara - Bruker

Bruker Vutara VXL is a super-resolution 3D microscope using single-molecule localization microscopy (SMLM) with patented bi-plane detection. It resolves molecular targets below the diffraction limit in three dimensions and, with integrated fluidics, supports multiplexed spatial genomics, transcriptomics and proteomics.

Specification

VendorBruker
Modalitysuper-resolution 3D microscopy (single-molecule localization microscopy, SMLM)
Tissuecells, cell cultures, tissue sections, whole organisms
Resolution20 nm lateral (XY), 50 nm axial (Z); finer with DNA-PAINT
Speciesnot species-specific (imaging platform)
BillingBy consultation (free)
The Bruker Vutara VXL in the Spatial Technologies Unit
The Bruker Vutara VXL in the Spatial Technologies Unit
Bruker Vutara VXL super-resolution microscope
Bruker Vutara VXL super-resolution microscope
Vutara VXL super-resolution: DNA-PAINT, 3D genome contact mapping and single-molecule localization
Vutara VXL super-resolution: DNA-PAINT, 3D genome contact mapping and single-molecule localization

Capabilities

  • Single-molecule localization microscopy (SMLM) with patented bi-plane 3D detection and dual-camera two-colour imaging.
  • Localization precision of 20 nm laterally (XY) and 50 nm axially (Z) for organic dyes, finer with DNA-PAINT.
  • Multiplexed imaging via integrated PlexFlo fluidics: spatial genomics, transcriptomics and proteomics.
  • Compatible techniques: PALM, dSTORM, DNA-PAINT, OligoSTORM and smFISH.

What you receive

  • super-resolution localization images (OME-TIFF)
  • H&E images where applicable
  • MD5 checksums at transfer

Access and priority

Internal clients (BIDMC, DF/HCC), external academic and non-profit clients, and industry clients all have equal priority. Projects begin upon sample receipt.